Simple molecule PGE2 map
PGE2@INNATE_IMMUNE_CELL_Cytosol

References
PMID:22025564
COX2 catalyses synthesis of PGE2 in MDSC.

PGE2@default

References
CASCADE:MIF
CASCADE:PGE2
 MDSC  map
PMID:22025564
COX2 catalyses synthesis of PGE2 in MDSC.
PGE2 induces expression of CXCR4 in MDSC
Inhibition of COX2 or the PGE2 receptors EP2/EP4 in MDSCs suppressed expression of CXCR4 and MDSC responsiveness to CXCL12 or ovarian cancer ascites.
PMID:12782713
MIF signal transduction initiated by binding to CD74.
CD74 Mediates MIF Induction of ERK-1/2 Phosphorylation, PGE2 Production, and Proliferation in macrophages.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PGE2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. PGE2@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. PGE2:​PTGER2@INNATE_IMMUNE_CELL_Membrane map
  2. PGE2:​PTGER4@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. PGE2@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_SUPRESSION@default map
  2. PGE2@default map + PTGER2@INNATE_IMMUNE_CELL_Membrane map → map PGE2:​PTGER2@INNATE_IMMUNE_CELL_Membrane map
  3. PGE2@default map + PTGER4@INNATE_IMMUNE_CELL_Membrane map → map PGE2:​PTGER4@INNATE_IMMUNE_CELL_Membrane map
  4. Arachidonic acid@INNATE_IMMUNE_CELL_Cytosol map → map PGE2@INNATE_IMMUNE_CELL_Cytosol map
  5. PGE2@INNATE_IMMUNE_CELL_Cytosol map → map PTGS2@INNATE_IMMUNE_CELL_Cytosol map
  6. PGE2@INNATE_IMMUNE_CELL_Cytosol map → map PGE2@default map
As Catalyser:
  1. THBS1@INNATE_IMMUNE_CELL_Cytosol map → map THBS1@default map
  2. CXCL12@TUMOR_CELL_AS_INDUCTOR map → map CXCL12@default map
  3. Adenylyl_cyclase*@INNATE_IMMUNE_CELL_Cytosol map → map Adenylyl_cyclase*@INNATE_IMMUNE_CELL_Cytosol map
  4. gCXCR4@INNATE_IMMUNE_CELL_Cytosol map → map rCXCR4@INNATE_IMMUNE_CELL_Cytosol map