Protein PTGER2 map

Identifiers
prostaglandin E receptor 2
HUGO:PTGER2 hgnc_id:HGNC:9594 HGNC:9594 ENTREZ:5732 UNIPROT:P43116

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
CASCADE:PGE
PMID:25916550
miR-149 targets IL-6 mRNA and is downregulated in GC CAFs
PGE2 receptor, PTGER2 and IL6, are potential targets of miR-149
PGE2 binds to EP2 and induces the hypermethylation and suppression of miR-149, reversing the downregulation of IL-6 and EP2 expression.
PMID:21209948
PGE2 can induce IL-6 expression in fibroblasts through EP2
 MDSC  map
CASCADE:PGE2
PMID:22025564
PGE2 induces expression of CXCR4 in MDSC
Inhibition of COX2 or the PGE2 receptors EP2/EP4 in MDSCs suppressed expression of CXCR4 and MDSC responsiveness to CXCL12 or ovarian cancer ascites.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. PTGER2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. PGE2:​PTGER2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. PGE2@default map + PTGER2@INNATE_IMMUNE_CELL_Membrane map → map PGE2:​PTGER2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. Adenylyl_cyclase*@INNATE_IMMUNE_CELL_Cytosol map → map Adenylyl_cyclase*@INNATE_IMMUNE_CELL_Cytosol map
  2. gCXCR4@INNATE_IMMUNE_CELL_Cytosol map → map rCXCR4@INNATE_IMMUNE_CELL_Cytosol map