Identifiers
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
HUGO:ID3, HGNC:5362, ENTREZ:3399, UNIPROT:Q02535 , GENECARDS:GC01M023884
HUGO:ID3
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / MIRNA_TF_IMMUNOSUPPRESSIVE
References
PMID:15121845
PMID:18832382
Id2 or Id3 can form complexes with TCF3 (E47), and inhibit the process of EMT.
Id2 and Id3 define the epithelial context that allows proper growth and differentiation responses to specific TGFB superfamily factors
PMID:15689496
Id2 (and Id3) must be down-regulated by TGFB pathway in order for EMT to occur.
ID2 is repressed by TGFB1 but induced by BMP7
Under conditions of Id2 knockdown, BMP-7 is capable of inducing significant alpha-smooth Actin level
MACROPHAGE
MDSC
CASCADE:LGALS1
CASCADE:IL10
PMID:21191065
regulatory effect of galectin-1 is mediated, in part, through its ability to induce, in an Id3 (inhibitor of DNA binding 3)-dependent manner, the expression of IL-10 in monocytes and MdDCs.
significantly increased IL-10 promoter activity was noted in CD14+ monocytes in the presence of A459-CM, NCI-H460-CM, or galectin-1. Increased IL-10 promoter activity was also found in cells overexpressing Id3
References
in_re423( Innate Immunity ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.