Protein TRAF3 map

Identifiers
HUGO:TRAF3

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
CASCADE:TLR2_4
PMID:16306937
IL10 and IFNB expression is TRAF3 dependent on mRNA level downstream of TLR4 signaling..

TRAF3@INNATE_IMMUNE_CELL_Cytosol

References
in_re423( Innate Immunity  map ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TRAF3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. TRAF3@INNATE_IMMUNE_CELL_Cytosol map → map TRAF3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
    2. gIFNB*@INNATE_IMMUNE_CELL_Cytosol map → map rINFB*@INNATE_IMMUNE_CELL_Cytosol map