Identifiers
HUGO:CCL2
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / RECRUITMENT_OF_IMMUNE_CELLS
References
PMID:27216177
PMID:24531940
Cancer-associated fibroblasts (CAFs) have been described to play critical roles in initiation, progression and metastasis of various cancers. However, the involvement of CAFs in oral cancer (OC) has not been well addressed. In this study, we demonstrate that CAFs, when cocultured with OC cells (OCCs), produce high levels of chemokine (C-C motif) ligand 2 (CCL2) and, subsequently, enhance endogenous reactive oxygen species production in cells. Oxidative stress stimulates expression of cell cycle progression proteins in OCCs, leading to promotion of OCC proliferation, migration, invasion and, OC tumor growth. On the other hand, oxidative stress triggered the activation of nuclear factor-kappaB (NF-??B) and STAT3 in CAFs, resulting in accelerating CCL2 expression.
PMID:18776941
Expression of VEGF and bFGF, but also IL-1??, MMP9, CCL2, and CXCL2 is STAT3-dependent in myeloid cells.
PMID:19732719??
Inhibition of TGF-?? signaling downregulates Arginase1, CCL5 and CCL2 expression and upregulates TNF, ICAM1,CCL3 expression (mRNA) in tumor neutrophiles (TAN)
PMID:17404308
CSF1 induces IL10 and CCL2 mRNA expression in macrophages
Stat3 activity is required for tumor factor???induced migration of ECs
References
in_re569( Innate Immunity ):
PMID:17404308, PMI:17404308
CSF1 upregulates expression of CCL2 probably via CSF1R.