RNA CCL2 map

Identifiers
HUGO:CCL2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
CASCADE:PLAU
PMID:27216177
FAP as a persistent activator of fibroblastic STAT3 through a uPAR-dependent FAK-Src-JAK2 signaling pathway.
STAT3 inducec CLL2 expression downstream of this signaling.
PMID:18776941
Expression of VEGF and bFGF, but also IL-1??, MMP9, CCL2, and CXCL2 is STAT3-dependent in myeloid cells.
PMID:17404308
CSF1 induces IL10 and CCL2 mRNA expression in macrophages

rCCL2@INNATE_IMMUNE_CELL_Cytosol

References
in_re569( Innate Immunity  map ):
PMID:17404308, PMI:17404308
CSF1 upregulates expression of CCL2 probably via CSF1R.
in_re571( Innate Immunity  map ):
PMID:17681149
PPARG participates in inhibition of secretion of proinflammatory molecules, such as CCL-3, TNF, and MCP-1 (CCL-2).
PMID:23508573
HMGB1 induces secretion of CCL2, CCL3 and CXCL10 (IP-10) via TLR4 pathway.
PMID:19915063
Phosphorylated STAT1??is critical for IFN-gamma-induced (CCL2)MCP-1 production.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rCCL2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gCCL2@INNATE_IMMUNE_CELL_Cytosol map → map rCCL2@INNATE_IMMUNE_CELL_Cytosol map
    2. rCCL2@INNATE_IMMUNE_CELL_Cytosol map → map CCL2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: