Identifiers
HUGO:HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / METABOLIC
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / FATTY_ACID_BIOSYNTHESIS
Regulated Cell Death / GLUCOSE_METABOLISM
Regulated Cell Death / RCD_GENES
Innate Immunity / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
Innate Immunity / MIRNA_TF_IMMUNOSUPPRESSIVE
References
PMID:20535745
junD???/??? fibroblasts exhibit features of carcinoma-associated myofibroblasts.
The expression of the chemokine CXCL12 was increased in junD???/??? fibroblasts
HIF-1?? protein accumulates in junD???/??? fibroblasts and mice (Gerald et al, 2004; Laurent et al, 2008), the up-regulation of CXCL12 in junD???/??? fibroblasts could be mediated, at least partly, through HIF. Specific inhibition of HIF-1?? by siRNA strongly reduced HIF-1?? mRNA levels (Fig S3A) and decreased the expression of its target gene, CXCL12
PMID:20194441
IFNG enhanced the synthesis of HIF-1A mRNA.
PMID:24006507
HIF1a induces MIF expression of macrophages after hypoxia.
IL4+IL13 inhibit MIF expression via inhibition of HIF1a expression.
PMID:22067385
c-MYC is expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
IL4 downregulates HIF1a translation