Protein IL4R map

Identifiers
HUGO:IL4R

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / MARKERS_MDSC  map
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
PMID:14610620, PMID:12223527
IL13 acts via IL4 receptor type 2, which contains two subunits IL4R and IL13RA1
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4R????and common gamma-chain (IL-2R??);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:24030977
SCF2 (GM-CSF) promotes the immunosuppressive activity of glioma-infiltrating myeloid cells (MDSC) through upregulation of expression of interleukin-4 receptor-??
ARG1, TGFB, COX2 expression is downregulated in IL4R-/- MDSC (probably via STAT3 and MYC).

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL4R@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_MDSC
  1. IL4R@MARKERS_MDSC map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL2RG:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  2. IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  3. IL2RG:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  4. IL13RA1:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  5. IL13:​IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  6. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  7. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  8. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  9. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  10. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  11. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL4@default map + IL2RG:​IL4R@INNATE_IMMUNE_CELL_Membrane map → map IL2RG:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  2. IL4@default map + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map → map IL13RA1:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  3. IL13@default map + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map → map IL13:​IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  4. IL2RG:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK3@INNATE_IMMUNE_CELL_Cytosol map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  5. IL13RA1:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  6. IL13:​IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  7. rIL4R@INNATE_IMMUNE_CELL_Cytosol map → map IL4R@INNATE_IMMUNE_CELL_Membrane map
  8. IL2RG@INNATE_IMMUNE_CELL_Membrane map + IL4R@INNATE_IMMUNE_CELL_Membrane map → map IL2RG:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  9. IL13RA1@INNATE_IMMUNE_CELL_Membrane map + IL4R@INNATE_IMMUNE_CELL_Membrane map → map IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  10. IL2RG@INNATE_IMMUNE_CELL_Membrane map + IL4R@INNATE_IMMUNE_CELL_Membrane map → map IL2RG:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  11. IL13RA1@INNATE_IMMUNE_CELL_Membrane map + IL4R@INNATE_IMMUNE_CELL_Membrane map → map IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map
  12. IL4@default map + IL2RG:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK3@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  13. IL4@default map + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  14. IL13@default map + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. JAK1@INNATE_IMMUNE_CELL_Cytosol map → map JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. TYK2@INNATE_IMMUNE_CELL_Cytosol map → map TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. JAK2@INNATE_IMMUNE_CELL_Cytosol map → map JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. gTIMP3@INNATE_IMMUNE_CELL_Cytosol map → map rTIMP3@INNATE_IMMUNE_CELL_Cytosol map
  5. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  6. IRS2@INNATE_IMMUNE_CELL_Cytosol map → map IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  7. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  8. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  9. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  10. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  11. gIL18@INNATE_IMMUNE_CELL_Cytosol map → map rIL18@INNATE_IMMUNE_CELL_Cytosol map
  12. gINHBA@INNATE_IMMUNE_CELL_Cytosol map → map rINHBA@INNATE_IMMUNE_CELL_Cytosol map
  13. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map