Identifiers
HUGO:IL13

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CYTOKINES_CHEMOKINES_PRODUCTION 
 Innate Immunity   / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS 
 Innate Immunity   / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS 

References
PMID:26755705
PMID:20184663
CAFs may also directly influence the polarization of macrophages toward an M2 phenotype: IL-13, one of the key cytokines driving M2-like polarization of macrophages, was shown to be secreted by CAFs
PMID:12401408
IL13 is assosiated with M2 phenotype of macrophages
PMID:14610620, PMID:12223527
IL13 acts via IL4 receptor type 2, which contains two subunits IL4R and IL13RA1
PMID:14610620
Other receptor of IL13 is IL13RA2
PMID:18451175, PMID:14657224
IL13 signaling via IL13RA2 induces TGFB production in MDSC.
PMID:18250477
IL-4 or IL-13 stimulated the release of galectin-3
into the culture media in both BMDMs and PBMs.
PMID:21097505
IL-13 upregulates expression of SOCS1
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+??mobilization signaling and assosiation of IRS2 and PLCG1
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18

1. IL13@INNATE_IMMUNE_CELL_Cytosol

1. IL13@default

1. IL13:​IL13RA2@INNATE_IMMUNE_CELL_Membrane
2. IL13:​IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane
3. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane
4. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane

1. IL13@default + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane → IL13:​IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane
2. IL13:​IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol + JAK1@INNATE_IMMUNE_CELL_Cytosol → IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane
3. IL13@INNATE_IMMUNE_CELL_Cytosol → IL13@default
4. IL13@INNATE_IMMUNE_CELL_Cytosol → IL13@default
5. IL13@INNATE_IMMUNE_CELL_Cytosol → IMMUNE_SUPRESSION@default
6. IL13RA2@INNATE_IMMUNE_CELL_Membrane + IL13@default → IL13:​IL13RA2@INNATE_IMMUNE_CELL_Membrane
7. rIL13@INNATE_IMMUNE_CELL_Cytosol → IL13@INNATE_IMMUNE_CELL_Cytosol
8. IL13@default + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane + JAK2@INNATE_IMMUNE_CELL_Cytosol + JAK1@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol → IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane

1. TYK2@INNATE_IMMUNE_CELL_Cytosol → TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol
2. JAK2@INNATE_IMMUNE_CELL_Cytosol → JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol
3. LGALS3@INNATE_IMMUNE_CELL_Cytosol → LGALS3@default
4. TGFB*@INNATE_IMMUNE_CELL_Cytosol → TGFB*@default
5. PLCG1@INNATE_IMMUNE_CELL_Cytosol → PLCG1|​pho@INNATE_IMMUNE_CELL_Cytosol
6. STAT3@INNATE_IMMUNE_CELL_Cytosol → STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
7. IRS2@INNATE_IMMUNE_CELL_Cytosol → IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol
8. STAT1@INNATE_IMMUNE_CELL_Cytosol → STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
9. STAT6@INNATE_IMMUNE_CELL_Cytosol → STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
10. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol → rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
11. gIL23A@INNATE_IMMUNE_CELL_Cytosol → rIL23A@INNATE_IMMUNE_CELL_Cytosol
12. gIL18@INNATE_IMMUNE_CELL_Cytosol → rIL18@INNATE_IMMUNE_CELL_Cytosol
13. gINHBA@INNATE_IMMUNE_CELL_Cytosol → rINHBA@INNATE_IMMUNE_CELL_Cytosol
14. gSOCS1@INNATE_IMMUNE_CELL_Cytosol → rSOCS1@INNATE_IMMUNE_CELL_Cytosol
15. STAT6@INNATE_IMMUNE_CELL_Cytosol → STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
16. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol → IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol
17. gHIF1A@INNATE_IMMUNE_CELL_Cytosol → rHIF1A@INNATE_IMMUNE_CELL_Cytosol