Protein SOCS1 map

Identifiers
suppressor of cytokine signaling 1
HUGO:SOCS1 HGNC:19383 ENTREZ:8651 UNIPROT:O15524
HUGO:SOCS1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
SOCS-1 decreases IFNG signaling via inhiviting the catalytic activity of JAKs.
PMID:12811837
SOCS-1 overexpression resulted in a nearly complete loss of IFNG responsiveness in macrophages.
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:12193701
INFG upregulates TNFR1 and RIPK1 expression, probably via JAK/STAT1 pathway
because this expression is inhibited in presense of SOCS1.

SOCS1@INNATE_IMMUNE_CELL_Cytosol

References
in_re446( Innate Immunity  map ):
PMID:23124025
Tyk2 IS required for Stat6 (TYR641) activation in monocytes stimulated with IL-13.
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
IL-4, in contrast to IL-13, induced very low levels of phosphorylation of Stats 1 and 5 and a more robust phosphorylation of Stat3 and Stat6.
Jak1 is required for Stat6 (TYR641) activation in monocytes stimulated with IL-4
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:21469115
PI3K signaling is involved in STAT6 activation.
in_re721( Innate Immunity  map ):
PMID:12193701
INFG upregulates TNFR1 expression, probably via JAK/STAT1 pathway
because this expression is inhibited in presense of SOCS1.
in_re723( Innate Immunity  map ):
INFG upregulates RIPK1 expression, probably via JAK/STAT1 pathway

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SOCS1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rSOCS1@INNATE_IMMUNE_CELL_Cytosol map → map SOCS1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. IFNG|​hm2@default map + IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
    2. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    3. gTNFR1*@INNATE_IMMUNE_CELL_Cytosol map → map rTNFR1*@INNATE_IMMUNE_CELL_Cytosol map
    4. gRIPK1@INNATE_IMMUNE_CELL_Cytosol map → map rRIPK1@INNATE_IMMUNE_CELL_Cytosol map
    5. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map