Protein TGFBR2 map

Identifiers
transforming growth factor beta receptor 2
HUGO:TGFBR2 hgnc_id:HGNC:11773 HGNC:11773 ENTREZ:7048 UNIPROT:P37173
transforming growth factor, beta receptor II (70/80kDa)
HUGO:TGFBR2, HGNC:11773, ENTREZ:7048, UNIPROT:P37173, GENECARDS:GC03P030623
HUGO:TGFBR2
MFS2 "transforming growth factor beta receptor II (70-80kD)"
HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:24132110,PMID:15265520
TGFB1, TGFB2, TGFB3 ligands bind to the type 2 TGF?? receptor (TGFBR2), which causes recruitment and phosphorylation of TGFBR1, resulting in downstream signalling activation.
PMID:24336330
TGFBR2 in CAFs
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
PMID:24132110
PMID:22703233
TGFBR2 upregulates expression of markers M2 activation as ARG1, MCR2 and LGALS3 (galecsin3) and induces AKT activation.
TGF-beta is known to cause a hetero-oligomerisation of the TGFBR1/TGFBR2 complex consisting of two TGFBR1 and two TGFBR2 molecules to activate it (not modelled).
Besides cellular stresses the SAPK pathways are also activated by cytokines such as TGF-beta. Smad-dependent gene expression can provoke P38 activation in response to TGFbeta.
PMID:20060931 PMID:21614932

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TGFBR2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TGFBR1@INNATE_IMMUNE_CELL_Membrane map + TGFBR2@INNATE_IMMUNE_CELL_Membrane map + TGFB*@default map → map TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane map
  2. rTGFBR2@INNATE_IMMUNE_CELL_Cytosol map → map TGFBR2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gLGALS3@INNATE_IMMUNE_CELL_Cytosol map → map rLGALS3@INNATE_IMMUNE_CELL_Cytosol map
  2. gMRC2@MARKERS_MACROPHAGE map → map rMRC2@MARKERS_MACROPHAGE map
  3. gCCL5@INNATE_IMMUNE_CELL_Cytosol map → map rCCL5@INNATE_IMMUNE_CELL_Cytosol map
  4. AKT*@INNATE_IMMUNE_CELL_Cytosol map → map AKT*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. SMAD3@INNATE_IMMUNE_CELL_Cytosol map → map SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. SMAD2@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  7. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map
  8. gCCL3@INNATE_IMMUNE_CELL_Cytosol map → map rCCL3@INNATE_IMMUNE_CELL_Cytosol map
  9. gCCL2@INNATE_IMMUNE_CELL_Cytosol map → map rCCL2@INNATE_IMMUNE_CELL_Cytosol map