SMAD2

Protein SMAD2

Identifiers
SMAD family member 2
HUGO:SMAD2 hgnc_id:HGNC:6768 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796
HUGO:SMAD2, HGNC:6768, ENTREZ:4087, UNIPROT:Q15796, GENECARDS:GC18M045357
"MAD mothers against decapentaplegic homolog 2 (Drosophila)" MADH2 "SMAD mothers against DPP homolog 2 (Drosophila)"
HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796
HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796 GENECARDS:SMAD2 REACTOME:405890 KEGG:4087 ATLASONC:SMAD2ID370 WIKI:SMAD2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / GROWTH_FACTORS_SIGNALING_PATHWAYS
EMT Senescence / EMT_REGULATORS
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / WNT_CANONICAL

References
CASCADE:TGFB
PMID:15265520 , PMID:11279127
TGF/SMAD pathway regulates genes involved in extracellular matrix remodeling in fibroblasts.
For the TGF-?? pathway, the Smad proteins, Smad2 and Smad3, are ligand-responsive
PMID:16179589
NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.
On stimulation with TGF-beta1, Nox4 mRNA is dramatically upregulated.
Depletion of Nox4 but not Nox5 inhibits baseline and TGF-beta1 stimulation of Smad 2/3 phosphorylation
PMID:9670020
Smad2 and Smad3 form homo-oligomers upon phosphorylation by the constitutively active TGFBR1
This oligomerization does not require Smad4.
PMID:11074002
Upon TGFB signaling, complex formation between Smad4 and activated Smad2 or -3 leads to nuclear accumulation of Smad4 through inhibition of its nuclear export.
After prolonged TGFB signaling Smad2 becomes dephosphorylated and Smad2 and Smad4 accumulate back in the cytoplasm
CASCADE:IL12
CASCADE:IL18
PMID:16713975
SMAD2, SMAD3 and SMAD4 participate in suppression of TBX21 (T-BET) promoter activity downstream of TGFB.
costimulation of NK cells with IL-12 and IL-18 downregulated SMAD2 transcript.
PMID:21042762
Inhibition of TGF-?? signalinginduced phenotypic maturation of BM-DCs and human DCs and improved their abilities to produce IL-12 in a dose-dependent manner via SMADs.
PMID:22331441
Smad2/3 inhibited IFN-?? production by suppressing IRF3 transcriptional activity.
Smad2/3 somehow suppresses IRF3 phosphorylation in macrophages
Smad2 and Smad3 negatively regulate iNOS induction in macrophages by suppressing multiple steps in the IRF3-IFN-??-STAT1 pathway
TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes.
PMID:21614932

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

SMAD2@INNATE_IMMUNE_CELL_Cytosol
SMAD2|pho@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

SMAD2|pho:SMAD4@INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: