Identifiers
transforming growth factor beta receptor 1
HUGO:TGFBR1 hgnc_id:HGNC:11772 HGNC:11772 ENTREZ:7046 UNIPROT:P36897
HUGO:TGFBR1, HGNC:11772, ENTREZ:7046, UNIPROT:P36897, GENECARDS:GC09P101867
HUGO:TGFBR1
"transforming growth factor beta receptor I (activin A receptor type II-like kinase 53kD)"
HUGO:TGFBR1 HGNC:11772 ENTREZ:7046 UNIPROT:P36897
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / GROWTH_FACTORS_SIGNALING_PATHWAYS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
PMID:24132110, PMID:15265520
TGFB1, TGFB2, TGFB3 ligands bind to the type 2 TGF?? receptor (TGFBR2), which causes recruitment and phosphorylation of TGFBR1, resulting in downstream signalling activation.
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
PMID:24132110
TGF-beta is known to cause a hetero-oligomerisation of the TGFBR1/TGFBR2 complex consisting of two TGFBR1 and two TGFBR2 molecules to activate it (not modelled).
Besides cellular stresses the SAPK pathways are also activated by cytokines such as TGF-beta. Smad-dependent gene expression can provoke P38 activation in response to TGFbeta.
PMID:20060931 PMID:21614932
+ TGFBR2@INNATE_IMMUNE_CELL_Membrane + TGFB*@default → TGFB*:TGFBR1:TGFBR2@INNATE_IMMUNE_CELL_Membrane
→ rCCL5@INNATE_IMMUNE_CELL_Cytosol
→ SMAD3|pho@INNATE_IMMUNE_CELL_Cytosol
→ SMAD2|pho@INNATE_IMMUNE_CELL_Cytosol
→ O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol
→ rCCL3@INNATE_IMMUNE_CELL_Cytosol
→ rCCL2@INNATE_IMMUNE_CELL_Cytosol