Complex TGFB*:TGFBR1:TGFBR2 map
Complex composition:

  1. TGFBR1 map
  2. TGFBR2 map
  3. TGFB* map

TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:TGFB*:TGFBR1:TGFBR2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:TGFB
PMID:11792802, PMID:12809600
The canonical TGFB signalling pathway involves phosphorylation of the carboxy-terminal serine residue of the internal modulator SMAD proteins,
SMAD2 or SMAD3, by the activated receptors. This phosphorylation induces oligomerization of SMAD2 or SMAD3 with SMAD4, which is necessary for nuclear translocation
in_re477( Innate Immunity  map ):
PMID:19732719
Inhibition of TGF-?? signaling??in vivo??increases CD11b+??cell cytotoxicity via an oxygen radical-dependent mechanism (superoxide?? and H2O2 production) in neutrophils
in_re568( Innate Immunity  map ):
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters and transrepresses expression NOS2, Ccl3, Ccl7, Cxcl10
in_re569( Innate Immunity  map ):
PMID:17404308, PMI:17404308
CSF1 upregulates expression of CCL2 probably via CSF1R.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TGFBR1@INNATE_IMMUNE_CELL_Membrane map + TGFBR2@INNATE_IMMUNE_CELL_Membrane map + TGFB*@default map → map TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gCCL5@INNATE_IMMUNE_CELL_Cytosol map → map rCCL5@INNATE_IMMUNE_CELL_Cytosol map
  2. SMAD3@INNATE_IMMUNE_CELL_Cytosol map → map SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. SMAD2@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map
  5. gCCL3@INNATE_IMMUNE_CELL_Cytosol map → map rCCL3@INNATE_IMMUNE_CELL_Cytosol map
  6. gCCL2@INNATE_IMMUNE_CELL_Cytosol map → map rCCL2@INNATE_IMMUNE_CELL_Cytosol map