Protein ITGB1 map

Identifiers
integrin subunit beta 1
HUGO:ITGB1 hgnc_id:HGNC:6153 HGNC:6153 ENTREZ:3688 UNIPROT:P05556
HUGO:ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HUGO:ITGB1, HGNC:6153, ENTREZ:3688, UNIPROT:P05556, GENECARDS:GC10M033189

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / INTEGRINS  map

References
CASCADE:INTEGRIN
CASCADE:PLAU
PMID:9456329;PMID:11112697
Integrin ??2??1 is a heterodimeric adhesive protein receptor belonging to the ??1 subfamily. It serves as a collagen receptor on fibroblasts and platelets and additionally as a laminin receptor on epithelial and endothelial cells
Collagen signaling nduces NF-??B Activity in fibroblasts probably via this receptor.
PMID:22470492
Treatment with ??v??5 blocking antibody reduces integrin ??1/matrix binding.
increase in ??5 cell-surface levels after uPA-silencing promotes ??1-mediated cell attachment that correlates with a decrease in integrin ??1 activity.
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:19487819
During gastrulation, type 1 EMT is associated with de novo expression of a5b1, which is a receptor for fibronectin.
Type 2 EMT in experimental kidney fibrosis is associated with increased a5 integrin expression.
PMID:9003039
L1 also interacts heterophilically with laminin in the context of mouse small cerebellar neurons
Integrins (b1, a3, a6) could be shown to bind to laminin by a b1-dependent adhesion mechanism.
L1 was demonstrated to bind in a concentration-dependent and saturating manner to laminin.
Furthermore, antibodies to the Ig-like domains of L1 and b1 integrin inhibited partially cell adhesion to laminin.
 NATURAL_KILLER  map
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:19454690
NKG2D ligation leads to increased adhesion and recruitment of beta1 and beta2 integrins to the cytotoxic synapse.
PMID:9973479
Beta 1 integrin cross-linking inhibits CD16-induced phospholipase D and secretory phospholipase A2 activity and granule exocytosis in human NK cells.
PMID:9763606
Cross-linking of ??1 Integrins on Human NK Cells Induces Shc Tyrosine Phosphorylation and Grb2 Association via Pyk-2end
resulted in RAS/ERK activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGB1@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
  2. (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map
  3. FN1:​ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map → map (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map
  2. ITGB1@INNATE_IMMUNE_CELL_Membrane map + ITGA4@INNATE_IMMUNE_CELL_Membrane map → map (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map
  3. FN1@default map + ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map → map FN1:​ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
  4. ITGB1@INNATE_IMMUNE_CELL_Membrane map + ITGA5@INNATE_IMMUNE_CELL_Membrane map → map ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. FYN@INNATE_IMMUNE_CELL_Cytosol map → map FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. PTK2B@INNATE_IMMUNE_CELL_Cytosol map → map PTK2B|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. PLD*@INNATE_IMMUNE_CELL_Cytosol map → map PLD*@INNATE_IMMUNE_CELL_Cytosol map
  5. PLA2G2A@INNATE_IMMUNE_CELL_Cytosol map → map PLA2G2A|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. PTK2@INNATE_IMMUNE_CELL_Cytosol map → map PTK2@INNATE_IMMUNE_CELL_Cytosol map
  7. LYN@INNATE_IMMUNE_CELL_Cytosol map → map LYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map