Protein PTK2B map

Identifiers
protein tyrosine kinase 2 beta
FAK2, "protein tyrosine kinase 2 beta", "PTK2B protein tyrosine kinase 2 beta"
HUGO:PTK2B HGNC:9612 ENTREZ:2185 UNIPROT:Q14289

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map

References
 NATURAL_KILLER  map
CASCADE:INTEGRIN_A4B1
PMID:10679059, PMID:12626562
PTK2B, PYK2. Binding of NK cells to sensitive target cells or ligation of ??2 integrins results in a rapid induction of Pyk2 phosphorylation and activation.
y contrast, no detectable Pyk2 tyrosine phosphorylation is found upon CD16 stimulation.
Pyk2 activation is a crucial event for natural but not Ab-dependent cytotoxicity.
Ligation of Beta2 integrins on NK cells resulted in Pyk2-dependent Erk activation, probaby via VAV1/RAC1 pathway.
Pyk-2-mediated control of integrin-triggered Rac-1 activation involves the regulation of Vav tyrosine phosphorylation.
PMID:9763606
Cross-linking of ??1 Integrins on Human NK Cells Induces Shc Tyrosine Phosphorylation and Grb2 Association via Pyk-2end
resulted in RAS/ERK activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PTK2B@INNATE_IMMUNE_CELL_Cytosol map
  2. PTK2B|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PTK2B@INNATE_IMMUNE_CELL_Cytosol map → map PTK2B|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. VAV1@INNATE_IMMUNE_CELL_Cytosol map → map VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    2. GRB2@INNATE_IMMUNE_CELL_Cytosol map + SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol map → map GRB2:​SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol map