Complex ITGA4:ITGB1 map
Complex composition:

  1. ITGA4 map
  2. ITGB1 map

(ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:ITGA4:ITGB1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / INTEGRINS  map

References
 NATURAL_KILLER  map
CASCADE:NKG2D
CASCADE:INTEGRIN_A4B1
PMID:12626562, PMID:19454690
VCAM1 is a ligand for alpha-4/beta-1 integrin cells. NKG2D ligation leads to increased adhesion NK cells to VCAM1 and ICAM1 and recruitment of integrins to the cytotoxic synapse.
PMID:9973479
Beta 1 integrin cross-linking inhibits CD16-induced phospholipase D and secretory phospholipase A2 activity and granule exocytosis in human NK cells.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map → map (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map
  2. ITGB1@INNATE_IMMUNE_CELL_Membrane map + ITGA4@INNATE_IMMUNE_CELL_Membrane map → map (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. FYN@INNATE_IMMUNE_CELL_Cytosol map → map FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. PTK2B@INNATE_IMMUNE_CELL_Cytosol map → map PTK2B|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. PLD*@INNATE_IMMUNE_CELL_Cytosol map → map PLD*@INNATE_IMMUNE_CELL_Cytosol map
  5. PLA2G2A@INNATE_IMMUNE_CELL_Cytosol map → map PLA2G2A|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. PTK2@INNATE_IMMUNE_CELL_Cytosol map → map PTK2@INNATE_IMMUNE_CELL_Cytosol map
  7. LYN@INNATE_IMMUNE_CELL_Cytosol map → map LYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map