Protein LYN map

Identifiers
HUGO:LYN

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / ACTIVATING_CHECKPOINTS  map
 Innate Immunity  map  / FC_RECEPTORS  map

References
PMID:26552706
 NATURAL_KILLER  map
 MACROPHAGE  map
 MAST_CELL  map
CASCADE:FCER
CASCADE:FCAR
CASCADE:Fc_gamma_RI
CASCADE:Fc_gamma_RII
CASCADE:Fc_gamma_RIII
CASCADE:INTEGRIN_A4B1
PMID:8892616
Beta1 integrin-mediated activation of focal adhesion kinase and its association with Fyn and Zap-70 in human NK cells.
FN adhesion-induced activity of the PTKs pl2SFAK, Fyn, Lyn,
and Zap-70. Lyn activity was induced by cross-linking of a4pI integrins, but not by cross-linking
of asp, either with a-specific mAbs.
PMID:21910624
The ITAM can be part of the same polypeptidic chain that engages the ligand, as in the case of Fc??RIIA and Fc??RIIC, or of a separate ?? subunit that associates noncovalently with the ligand-binding subunit of the receptor, as in the case of Fc??RI and Fc??RIIIA. Upon receptor clustering, the ITAM associates with and becomes phosphorylated by Hck, Lyn (33, 34), and/or Fgr (35).
PMID:8132624
Hck, Lyn binds to Fc_gamma_RII (CD32) and phosphorylates it in monocytes.
PMID:8064233, PMID:12524384, PMID:24445665
Hck, Lyn binds to Fc_gamma_RI (cd64) in monocytes and probably
phosphorylate ignal transducing gamma subunit of the high-affinity IgE receptor (Fc epsilon RI gamma).
Induction of cytoplasmic protein tyrosine phosphorylation by Fc gamma RI cross-linking is known to be important in mediating Fc gamma RI-coupled effector functions.
Probably these kinases activate also IgE receptors directly
and FCAR and Fc_gamma_RIII complexes with Fc epsilon RI gamma.
PMID:19909365
Lyn is adaptor protein of IgE receptor signaling in mast cells

LYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

References
in_re258( Innate Immunity  map ):
PMID:8478617
Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells.
CD3 zeta is phosphorilated by LCK

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. LYN@INNATE_IMMUNE_CELL_Cytosol map
  2. LYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. LYN@INNATE_IMMUNE_CELL_Cytosol map → map LYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
    2. SLAMF7@TUMOR_CELL_AS_INDUCTOR_Membrane map + SLAMF7@INNATE_IMMUNE_CELL_Membrane map → map in_s5128
    3. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_gamma_RII_activating*@INNATE_IMMUNE_CELL_Membrane map → map Fc_gamma_RII_activating*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
    4. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_gamma_RI*@INNATE_IMMUNE_CELL_Membrane map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map FCER1G|​pho:​Fc_gamma_RI*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
    5. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCAR@INNATE_IMMUNE_CELL_Membrane map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map FCAR:​FCER1G|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
    6. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_epsilon_R*@INNATE_IMMUNE_CELL_Membrane map → map Fc_epsilon_R*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map