Identifiers
protein tyrosine kinase 2
HUGO:PTK2 hgnc_id:HGNC:9611 HGNC:9611 ENTREZ:5747 UNIPROT:Q05397
References
CASCADE:INTEGRIN
PMID:12531888
Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase.
TGF-??1 induces tyrosine phosphorylation of focal adhesion kinase PTK2(FAK) including that of its autophosphorylation site, Tyr-397, an effect that is dependent on cell adhesion and is delayed relative to early Smad signaling. Pharmacologic inhibition of FAK or expression of kinase-deficient FAK, mutated by substituting Tyr-397 with Phe, inhibit TGF-??1-induced ??-smooth muscle actin expression, stress fiber formation, and cellular hypertrophy.
PMID:27216177; PMID:20027185
PlAUR induces FAK activation downstream of FAP, probably via activation of integrin signaling,
because Integrins are essential uPAR signalling co-receptors and a second uPAR ligand, the ECM protein vitronectin, is also crucial for this process.
NATURAL_KILLER
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:8892616
PTK2 (FAK)
Beta1 integrin-mediated activation of focal adhesion kinase and its association with Fyn and Zap-70 in human NK cells downstream of fibronectin.