Protein ITGA5 map

Identifiers
integrin subunit alpha 5
HUGO:ITGA5 hgnc_id:HGNC:6141 HGNC:6141 ENTREZ:3678 UNIPROT:P08648
HUGO:ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
HUGO:ITGA5, HGNC:6141, ENTREZ:3678, UNIPROT:P08648, GENECARDS:GC12M054789

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / INTEGRINS  map

References
CASCADE:INTEGRIN
PMID:18037882
Integrin a3 and a5 are important in leading fibroblasts in SCC.
siRNA against integrin 3 or integrin 5 in stromal fibroblasts would prevent the invasion of SCC cells and Figure 4C shows that siRNA-mediated depletion of either integrin 3 or integrin 5 in stromal fibroblasts, but not in SCC cells, reduced the collective invasion of SCC cells.
Several groups have shown that integrin a5 can activate Rho signalling16, 17, 18, and this result was confirmed in carcinoma-associated fibroblasts (data not shown). Integrin a3 was also important for force-mediated matrix remodelling, but we found no evidence that it regulated Rho activity (data not shown).
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:19487819
During gastrulation, type 1 EMT is associated with de novo expression of a5b1, which is a receptor for fibronectin.
Type 2 EMT in experimental kidney fibrosis is associated with increased a5 integrin expression.
 NATURAL_KILLER  map
CASCADE:INTEGRIN_A5B1
PMID:24202395, PMID:22067905

ITGA5@INNATE_IMMUNE_CELL_Cytosol

Identifiers
CHEBI:17552 KEGGCOMPOUND:C00035

References
 DENDRITIC_CELL  map

ITGA5@INNATE_IMMUNE_CELL_Membrane

Identifiers
CHEBI:17552 KEGGCOMPOUND:C00035

References
 DENDRITIC_CELL  map

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ITGA5@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGA5@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
  2. FN1:​ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. FN1@default map + ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map → map FN1:​ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
  2. ITGB1@INNATE_IMMUNE_CELL_Membrane map + ITGA5@INNATE_IMMUNE_CELL_Membrane map → map ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. FYN@INNATE_IMMUNE_CELL_Cytosol map → map FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. PLD*@INNATE_IMMUNE_CELL_Cytosol map → map PLD*@INNATE_IMMUNE_CELL_Cytosol map
  4. PtdIns(4)-P@INNATE_IMMUNE_CELL_Cytosol map → map PIP2*@INNATE_IMMUNE_CELL_Cytosol map
  5. PLA2G2A@INNATE_IMMUNE_CELL_Cytosol map → map PLA2G2A|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. PTK2@INNATE_IMMUNE_CELL_Cytosol map → map PTK2@INNATE_IMMUNE_CELL_Cytosol map