Protein IFNA* map

Identifiers
HUGO:IFNA1 HUGO:IFNA2 HUGO:IFNA4 HUGO:IFNA5 HUGO:IFNA6 HUGO:IFNA7 HUGO:IFNA8 HUGO:IFNA10 HUGO:IFNA13 HUGO:IFNA14 HUGO:IFNA16 HUGO:IFNA17 HUGO:IFNA21

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION  map

References
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
 MAST_CELL  map
CASCADE:IFNAB
PMID:15289500
Lytic function by NK cells and their ability to kill MHC-negative targets was regulated by type I IFNs produced by activated DCs.
PMID:11449378
IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12.
IFN-????? and IL-12 induce tyrosine phosphorylation and DNA binding of Stat4 to IFN-????? promoter GAS element
PMID:22649192
miR-378 and miR-30e suppress IFN-?????upregulated granzyme B and perforin expression in human NK cells.
miR-378 and miR-30e are markedly decreased in activated NK cells by IFNA,
miR-378 and miR-30e directly targeted granzyme B and perforin, respectively and suppress of human NK cell cytotoxicity.
http://www.tandfonline.com/doi/abs/10.4161/21624011.2014.948705#.VJLI5efuK2s
IFN?? improves the degranulation capability of NK cells against target cancer cells in a PKC-??-dependent fashion both ex vivo and in vivo. Furthermore, IFN?? induces PKC-?? auto-phosphorylation in NK cells.
PMID:11207245
IFNA induces IL10 production in Dcs
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18

IFNA*@default

References
in_re181( Innate Immunity  map ):
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+??mobilization signaling and assosiation of IRS2 and PLCG1
PMID:7890616
PCL (probably PCLG1) induces t hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+??release downstream of IL13.
in_re428( Innate Immunity  map ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
in_re573( Innate Immunity  map ):
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters and transrepresses expression NOS2, Ccl3, Ccl7, Cxcl10

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IFNA*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. IFNA*@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. IFNA*@INNATE_IMMUNE_CELL_Cytosol map → map IFNA*@default map
    2. IFNA*@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
    3. rINFA*@INNATE_IMMUNE_CELL_Cytosol map → map IFNA*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gMIR378@INNATE_IMMUNE_CELL_Cytosol map → map arMIR378@INNATE_IMMUNE_CELL_Cytosol map
    2. gMIR30E@INNATE_IMMUNE_CELL_Cytosol map → map arMIR30E@INNATE_IMMUNE_CELL_Cytosol map
    3. IFNAR1:​IFNAR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNAR1:​IFNAR2:​JAK1:​TYK2@INNATE_IMMUNE_CELL_Membrane map
    4. IL3RA@INNATE_IMMUNE_CELL_Cytosol map → map IL3RA@INNATE_IMMUNE_CELL_Membrane map
    5. PLCG2@INNATE_IMMUNE_CELL_Cytosol map → map PLCG2|​pho@INNATE_IMMUNE_CELL_Cytosol map
    6. PLCG1@INNATE_IMMUNE_CELL_Cytosol map → map PLCG1|​pho@INNATE_IMMUNE_CELL_Cytosol map
    7. gSH2D1A@INNATE_IMMUNE_CELL_Cytosol map → map rSH2D1A@INNATE_IMMUNE_CELL_Cytosol map
    8. IL10@INNATE_IMMUNE_CELL_Cytosol map → map IL10@default map
    9. gCCR7@INNATE_IMMUNE_CELL_Cytosol map → map rCCR7@INNATE_IMMUNE_CELL_Cytosol map
    10. CCR5@INNATE_IMMUNE_CELL_Cytosol map → map CCR5@INNATE_IMMUNE_CELL_Membrane map
    11. gCCL19@INNATE_IMMUNE_CELL_Cytosol map → map rCCL19@INNATE_IMMUNE_CELL_Cytosol map
    12. gCXCL10@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL10@INNATE_IMMUNE_CELL_Cytosol map
    13. gCCL18@INNATE_IMMUNE_CELL_Cytosol map → map rCCL18@INNATE_IMMUNE_CELL_Cytosol map