Protein TRAF2 map

Identifiers
HUGO:TRAF2
TNF receptor associated factor 2
HUGO:TRAF2 hgnc_id:HGNC:12032 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933
HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map
 Regulated Cell Death  map  / ER_STRESS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:17462996 PMID:19392652
PMID:21232017, PMID:21133840, PMID:18641653
TNF induces TRADD-dependent and RIPK1-dependent recruitment of TRAF2 to TNFR1.
TNFR2 interacts with TRAF2 and TRAF1.
PMID:24378531
TNF via TNFR2 ??induces??TRAF2??degradation.
PMID:23850759
PMID:15592525
TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2.
PMID:11274345

TRAF2@INNATE_IMMUNE_CELL_Membrane

References
in_re730( Innate Immunity  map ):
PMID:24378531
TNF via TNFR2 ??induces??TRAF2??degradation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TRAF2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TNF:​TNFR2*:​TRAF1:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  3. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
  2. TNF@default map + TNFR1*@INNATE_IMMUNE_CELL_Membrane map + TRADD@INNATE_IMMUNE_CELL_Membrane map + TRAF2@INNATE_IMMUNE_CELL_Membrane map + RIPK1@INNATE_IMMUNE_CELL_Membrane map + FADD@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  3. TNF@default map + TNFR2*@INNATE_IMMUNE_CELL_Membrane map + TRAF1@INNATE_IMMUNE_CELL_Membrane map + TRAF2@INNATE_IMMUNE_CELL_Membrane map → map TNF:​TNFR2*:​TRAF1:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  4. TRAF2@INNATE_IMMUNE_CELL_Membrane map → map degraded
As Catalyser:
  1. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. gIRF1@INNATE_IMMUNE_CELL_Cytosol map → map rIRF1@INNATE_IMMUNE_CELL_Cytosol map
  3. TRAF2@INNATE_IMMUNE_CELL_Membrane map → map degraded
  4. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map
  5. JNK*@INNATE_IMMUNE_CELL_Cytosol map → map JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  6. p38*@INNATE_IMMUNE_CELL_Cytosol map → map p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map