Protein TNFR1* map

Identifiers
TNF receptor superfamily member 1A
HUGO:TNFRSF1A hgnc_id:HGNC:11916 HGNC:11916 ENTREZ:7132 UNIPROT:P19438
HUGO:TNFRSF1A

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:21232017; PMID:18641653
TNF acts through two transmembrane receptors: TNF receptor 1 (TNFR1), also known as p55 or p60, and TNF receptor 2 (TNFR2), also known as p75 or p80.
TNF induces TRADD-dependent and RIPK1-dependent recruitment of TRAF2 to TNFR1.
TRADD is essential for TNFR1 signaling in MEFs
TRADD was also required for TRIF-dependent Toll-like receptor signaling in mouse embryonic fibroblasts but not macrophages
PMID:8910423
both TNFR1 and TNFR2 receptors play role in TNF signal transduction in mouse fibroblasts
PMID:21133840, PMID:24378531
TNF acts through two transmembrane receptors: TNF receptor 1 (TNFR1), also known as p55 or p60, and TNF receptor 2 (TNFR2), also known as p75 or p80. Macrophages are reported to express both receptors.

TNFR1*@INNATE_IMMUNE_CELL_Membrane

References
in_re729( Innate Immunity  map ):
PMID:14607933
TNF induces the association of STAT-1 and TNFR1 in a tyrosine phosphorylation-independent manner, and and this association attenuates TNF-alpha-mediated NF-kappaB activation but formation of the TNFR1:STAT-1?? complex is inhibited upon inclusion of IFNG . IFNG limits STAT-1 availability to the TNFR1 by depleting STAT from the cytoplasm, thus allowing for optimal NF-kappaB activation upon TNF ligation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TNFR1*@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. STAT1|​pho:​TNFR1*@INNATE_IMMUNE_CELL_Membrane map
  2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  3. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
  2. rTNFR1*@INNATE_IMMUNE_CELL_Cytosol map → map TNFR1*@INNATE_IMMUNE_CELL_Membrane map
  3. TNF@default map + TNFR1*@INNATE_IMMUNE_CELL_Membrane map + TRADD@INNATE_IMMUNE_CELL_Membrane map + TRAF2@INNATE_IMMUNE_CELL_Membrane map + RIPK1@INNATE_IMMUNE_CELL_Membrane map + FADD@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  4. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + TNFR1*@INNATE_IMMUNE_CELL_Membrane map → map STAT1|​pho:​TNFR1*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map
  3. JNK*@INNATE_IMMUNE_CELL_Cytosol map → map JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. p38*@INNATE_IMMUNE_CELL_Cytosol map → map p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map