Reaction heterodimer_association in_re729 map

STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + TNFR1*@INNATE_IMMUNE_CELL_Membrane map → STAT1|​pho:​TNFR1*@INNATE_IMMUNE_CELL_Membrane map

Reaction regulators:
Inhibition
  1. IFNG|​hm2@default map


References
PMID:14607933
TNF induces the association of STAT-1 and TNFR1 in a tyrosine phosphorylation-independent manner, and and this association attenuates TNF-alpha-mediated NF-kappaB activation but formation of the TNFR1:STAT-1?? complex is inhibited upon inclusion of IFNG . IFNG limits STAT-1 availability to the TNFR1 by depleting STAT from the cytoplasm, thus allowing for optimal NF-kappaB activation upon TNF ligation.