Identifiers
TGF-beta activated kinase 1/MAP3K7 binding protein 2
HUGO:TAB2 hgnc_id:HGNC:17075 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8
HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8
HUGO:TAB2
MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2"
HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CORE 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 
 Survival   / WNT_NON_CANONICAL 

References
PMID:12620219
IRAK-1 interacts with the downstream adaptor TRAF6,
resulting in formation of a complex that also includes TAK1 and TAB2.
IRAK-1 mediates the translocation of TRAF6, TAK1 and TAB2 to the cytosol,
where they form a multiprotein complex with other cytosolic proteins,
which are needed for stimulation of TAK1 kinase activity.
PMID:14660645, PMID:18264787, PMID:12620219

1. TAB2@INNATE_IMMUNE_CELL_Cytosol

1. (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol

1. MAP3K7@INNATE_IMMUNE_CELL_Cytosol + TAB2@INNATE_IMMUNE_CELL_Cytosol + TAB3@INNATE_IMMUNE_CELL_Cytosol → (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol

1. IKK_alpha_*|​hm2@INNATE_IMMUNE_CELL_Cytosol → IKK_alpha_*|​pho|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol
2. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol → IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol
3. MAP2K4@INNATE_IMMUNE_CELL_Cytosol → MAP2K4|​pho@INNATE_IMMUNE_CELL_Cytosol
4. MAP2K3@INNATE_IMMUNE_CELL_Cytosol → MAP2K3|​pho@INNATE_IMMUNE_CELL_Cytosol