Identifiers
TGF-beta activated kinase 1 and MAP3K7 binding protein 3
HUGO:TAB3 hgnc_id:HGNC:30681 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8
TGF-beta activated kinase 1/MAP3K7 binding protein 3
HUGO:TAB3 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8
HUGO:TAB3
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / TNF_RESPONSE
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:19161412, PMID:12620219
IRAK-1 interacts with the downstream adaptor TRAF6,
resulting in formation of a complex that also includes TAK1 and TAB2.
IRAK-1 mediates the translocation of TRAF6, TAK1 and TAB2 to the cytosol,
where they form a multiprotein complex with other cytosolic proteins,
which are needed for stimulation of TAK1 kinase activity.
K63-pUb-Traf6 can then recruit transforming growth factor ??-activated protein kinase (TAK1) in a complex with TAK1-binding protein 2 (TAB2) and TAB3, which both contain nuclear zinc finger motifs that interact with K63-polyubiquitin chains (41). This somehow activates TAK1, which then couples to the inhibitor of NF-??B (I??B) kinase (IKK) complex, which contains the scaffold protein NF-??B essential modulator (NEMO) and IKK2, the kinase responsible for phosphorylation of I??B.
PMID:23681101
+ TAB2@INNATE_IMMUNE_CELL_Cytosol + TAB3@INNATE_IMMUNE_CELL_Cytosol → (MAP3K7:TAB2:TAB3)|active@INNATE_IMMUNE_CELL_Cytosol
→ IKK_alpha_*|pho|hm2|active@INNATE_IMMUNE_CELL_Cytosol
→ IKBKG|ubi:IKK_beta_*|pho:MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol
→ MAP2K4|pho@INNATE_IMMUNE_CELL_Cytosol
→ MAP2K3|pho@INNATE_IMMUNE_CELL_Cytosol