Protein RIPK1 map

Identifiers
receptor interacting serine/threonine kinase 1
HUGO:RIPK1 hgnc_id:HGNC:10019 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546
receptor (TNFRSF)-interacting serine-threonine kinase 1
HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546
HUGO:RIPK1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map
 Regulated Cell Death  map  / ER_STRESS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:21232017; PMID:18641653
TNF induces TRADD-dependent and RIPK1-dependent recruitment of TRAF2 to TNFR1.
TRADD is essential for TNFR1 signaling in MEFs
PMID:26587781
PMID:19632174
RIP kinases at the crossroads of cell death and survival
PMID:19524513
PMID:28574505
PMID:23010170
PMID:26653790
erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3
PMID:21232017, PMID:21133840, PMID:18641653
TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane.
PMID:11274345

RIPK1@INNATE_IMMUNE_CELL_Cytosol

References
in_re884( Innate Immunity  map ):
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1.
PMID:21232017, PMID:21133840, PMID:17301840
PMID:24958845, PMID:24699077
The LUBAC complex ubiquitinates NEMO, a subunit of the IKK complex downstream of TNF and upregulates IkBa degradetion.
PMID:11280761
VEGF signaling blocs TNF-?? induced activation of I??B kinase (IKK complex).This decreased IKK activation correlated with the inhibition of I??B?? phosphorylation and degradation of I??B?? and I??B?? in HPCs, and this inhibition is inhdependent or FLT1 and KDR

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. RIPK1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. RIPK1@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
  2. rRIPK1@INNATE_IMMUNE_CELL_Cytosol map → map RIPK1@INNATE_IMMUNE_CELL_Membrane map
  3. TNF@default map + TNFR1*@INNATE_IMMUNE_CELL_Membrane map + TRADD@INNATE_IMMUNE_CELL_Membrane map + TRAF2@INNATE_IMMUNE_CELL_Membrane map + RIPK1@INNATE_IMMUNE_CELL_Membrane map + FADD@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map
  3. JNK*@INNATE_IMMUNE_CELL_Cytosol map → map JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. p38*@INNATE_IMMUNE_CELL_Cytosol map → map p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map