Identifiers
TNFRSF1A associated via death domain
HUGO:TRADD hgnc_id:HGNC:12030 HGNC:12030 ENTREZ:8717 UNIPROT:Q15628
HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628
HUGO:TRADD
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / INFLAMMATORY_SIGNALING_PATHWAYS
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / NECROPTOSIS
Regulated Cell Death / TNF_RESPONSE
Regulated Cell Death / TRAIL_RESPONSE
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
PMID:21232017; PMID:18641653
TRADD is an adaptor molecule important for transducing signals from TNFR1. After binding of TNF, TRADD is recruited to TNFR1 and interacts with the cytoplasmic death domain region of TNFR1 through homotypic interactions. The TNFR1-TRADD complex serves as scaffolding for the recruitment of other signaling molecules that mediate the downstream actions of TNF.
PMID:14730360
Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins.
PMID:11274345
→ FADD:RIPK1|ubi:TNF:TNFR1*:TRADD:TRAF2|ubi@INNATE_IMMUNE_CELL_Membrane
+ TNFR1*@INNATE_IMMUNE_CELL_Membrane + TRADD@INNATE_IMMUNE_CELL_Membrane + TRAF2@INNATE_IMMUNE_CELL_Membrane + RIPK1@INNATE_IMMUNE_CELL_Membrane + FADD@INNATE_IMMUNE_CELL_Membrane → FADD:RIPK1:TNF:TNFR1*:TRADD:TRAF2@INNATE_IMMUNE_CELL_Membrane
+ TAB2@INNATE_IMMUNE_CELL_Cytosol + TAB3@INNATE_IMMUNE_CELL_Cytosol → (MAP3K7:TAB2:TAB3)|active@INNATE_IMMUNE_CELL_Cytosol
→ IKBKG|ubi:IKK_beta_*|pho:MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol
→ JNK*|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ p38*|pho|active@INNATE_IMMUNE_CELL_Cytosol