Protein NKG2D* map

Identifiers
HUGO:KLRK1

References
 NATURAL_KILLER  map
CASCADE:NKG2D
CASCADE:TGFB
CASCADE:MIF
CASCADE:IL15
PMID:17100878
NKG2D plays a major role in triggering cytotoxicity against target cells, such as the murine lymphoma line YAC-1. NKG2D detects cell surface molecules distantly related to MHC class I proteins, which are induced by viral infection and tumor transformation. As with many other activating NK cell receptors, NKG2D does not signal on its own but requires a unique signaling adapter, called DAP10.
PMID:17070508
IL-2/IL-18 prevent the down-modulation of NKG2D by TGF-beta in NK cells via the c-Jun N-terminal kinase (JNK) pathway.
PMID:18490724, PMID:11777960
IL15 upregulates NKG2D surface expression in NK cells.
PMID:16339513
CLEC2D (LLT1) is a ligand for the inhibitory human KLRB1 (NKR-P1A) receptor.
LLT1 inhibits NK cytotoxicity induced by either the 2B4(CD48/CD244) pathway or the MICA/NKG2D pathway.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NKG2D*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. NKG2D*@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_NK
  1. NKG2D*@MARKERS_NK map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  2. DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. NKG2D*@INNATE_IMMUNE_CELL_Cytosol map → map NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  2. GRB2@INNATE_IMMUNE_CELL_Cytosol map + DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map → map DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  3. rNKG2D*@INNATE_IMMUNE_CELL_Cytosol map → map NKG2D*@INNATE_IMMUNE_CELL_Cytosol map
  4. NKG2D*@INNATE_IMMUNE_CELL_Membrane map + DAP10@INNATE_IMMUNE_CELL_Membrane map → map DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  2. VAV1@INNATE_IMMUNE_CELL_Cytosol map → map VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. LCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. CBL@INNATE_IMMUNE_CELL_Cytosol map → map CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. CD18*@INNATE_IMMUNE_CELL_Membrane map + CD11a*@INNATE_IMMUNE_CELL_Membrane map → map CD11a*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  6. ITGB1@INNATE_IMMUNE_CELL_Membrane map + ITGA4@INNATE_IMMUNE_CELL_Membrane map → map (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map