Protein DAP10 map

Identifiers
HUGO:DAP10

References
 NATURAL_KILLER  map
CASCADE:NKG2D
PMID:17100878
As with many other activating NK cell receptors, NKG2D does not signal on its own but requires a unique signaling adapter, called DAP10.
YINM motif of DAP10 functions as docking site for PI3K, which represents the major effector molecule downstream of NKG2D.
PMID:10426994, 16582911??
Phosphorylated DAP10 directly interacts with regulatory subunit (p85) of PI3K and activates downstream pathway.
Binding of DAP10 to either p85 or Grb2 alone is not sufficient to trigger DAP10-mediated cytotoxicity and that both binding sites are necessary for NKG2D-initiated killing.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. DAP10@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  2. DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. GRB2@INNATE_IMMUNE_CELL_Cytosol map + DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map → map DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  2. NKG2D*@INNATE_IMMUNE_CELL_Membrane map + DAP10@INNATE_IMMUNE_CELL_Membrane map → map DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  2. VAV1@INNATE_IMMUNE_CELL_Cytosol map → map VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. LCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. CBL@INNATE_IMMUNE_CELL_Cytosol map → map CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. CD18*@INNATE_IMMUNE_CELL_Membrane map + CD11a*@INNATE_IMMUNE_CELL_Membrane map → map CD11a*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  6. ITGB1@INNATE_IMMUNE_CELL_Membrane map + ITGA4@INNATE_IMMUNE_CELL_Membrane map → map (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map