Protein HMGB1 map

Identifiers
HUGO:HMGB1
high mobility group box 1
HUGO:HMGB1 hgnc_id:HGNC:4983 HGNC:4983 ENTREZ:3146 UNIPROT:P09429

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ER_STRESS  map
 Regulated Cell Death  map  / PYROPTOSIS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION  map

References
PMID:27192565 PMID:22842346
PMID:19931333
PMID:26618107
PMID:27048821
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
 MACROPHAGE  map
CASCADE:IL18
CASCADE:TLR2_4
CASCADE:IFNG
CASCADE:TNF
PMID:15802534
Activated NK cells release HMGB1, which promotes inflammation and induces DC maturation.
IL-18 induces HMGB1 secretion by NK cells
PMID:12646658
IFNG upregulates protein level and secretion of HMGB1 partially via TNF induction in macrophages

HMGB1@default

References
in_re640( Innate Immunity  map ):
PMID:10952726
HMGB1 upregulates protein level of IL1RN (IL1RA)
in_re702( Innate Immunity  map ):
PMID:16267105
Exposure of macrofages to HMGB1 resulted in rapid decreases in protein level of both TLR2 and TLR4??receptors.
PMID:11672593
CSF1 up-regulates both TLR2 and TLR4 surface expression
in_re704( Innate Immunity  map ):
PMID:12803886
MIF upregulates membrane expression of TLR4
in_re1364( Innate Immunity  map ):
PMID:16327802
IL13 and TNF together (but neither IL-13 nor TNF alone) upregulates TGFB1 expression downstream of IL13RA2.
IL13 and TNF inducese TGFB1 expression via AP-1 transcription factors.IL13 induces binding of c-jun and fra2 ti TGFB1 promotor, and TNF binding of c-jun, JunD and c-fos.
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages via TLR4-dependent mechanisms.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. HMGB1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. HMGB1@TUMOR_CELL_AS_INDUCTOR map
In compartment: default
  1. HMGB1@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. HMGB1@INNATE_IMMUNE_CELL_Cytosol map → map HMGB1@default map
    2. HMGB1@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
    3. HMGB1@TUMOR_CELL_AS_INDUCTOR map → map HMGB1@default map
    As Catalyser:
    1. CCL4@INNATE_IMMUNE_CELL_Cytosol map → map CCL4@default map
    2. CXCR4@INNATE_IMMUNE_CELL_Cytosol map → map CXCR4@INNATE_IMMUNE_CELL_Membrane map
    3. gTGFB1@INNATE_IMMUNE_CELL_Cytosol map → map rTGFB1@INNATE_IMMUNE_CELL_Cytosol map
    4. CCR7@INNATE_IMMUNE_CELL_Cytosol map → map CCR7@INNATE_IMMUNE_CELL_Membrane map
    5. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map → map CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane map
    6. gCLL4@INNATE_IMMUNE_CELL_Cytosol map → map rCCL4@INNATE_IMMUNE_CELL_Cytosol map
    7. rIL18@INNATE_IMMUNE_CELL_Cytosol map → map IL18@INNATE_IMMUNE_CELL_Cytosol map
    8. rIL1RN@INNATE_IMMUNE_CELL_Cytosol map → map IL1RN@INNATE_IMMUNE_CELL_Cytosol map
    9. TLR2/4*@INNATE_IMMUNE_CELL_Membrane map + LY96@INNATE_IMMUNE_CELL_Membrane map + TIRAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + CD14@INNATE_IMMUNE_CELL_Membrane map → map CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
    10. rTLR2@INNATE_IMMUNE_CELL_Cytosol map → map TLR2@INNATE_IMMUNE_CELL_Membrane map
    11. rTLR4@INNATE_IMMUNE_CELL_Cytosol map → map TLR4@INNATE_IMMUNE_CELL_Membrane map