Identifiers
HUGO:TGFB1
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
PMID:16327802
IL13 and TNF inducese TGFB1 expression via AP-1 transcription factors.IL13 induces binding of c-jun and fra2 ti TGFB1 promotor, and TNF binding of c-jun, JunD and c-fos.
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages.
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGF??, VEGF.
PMID:24030977
SCF2 (GM-CSF) promotes the immunosuppressive activity of glioma-infiltrating myeloid cells (MDSC) through upregulation of expression of interleukin-4 receptor-??
ARG1, TGFB, COX2 expression is downregulated in IL4R-/- MDSC (probably via STAT3 and MYC).
References
in_re1364( Innate Immunity ):
PMID:16327802
IL13 and TNF together (but neither IL-13 nor TNF alone) upregulates TGFB1 expression downstream of IL13RA2.
IL13 and TNF inducese TGFB1 expression via AP-1 transcription factors.IL13 induces binding of c-jun and fra2 ti TGFB1 promotor, and TNF binding of c-jun, JunD and c-fos.
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages via TLR4-dependent mechanisms.