Reaction transcription in_re1364 map

gTGFB1@INNATE_IMMUNE_CELL_Cytosol map → rTGFB1@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. MYC@INNATE_IMMUNE_CELL_Cytosol map
  2. STING*@INNATE_IMMUNE_CELL_Cytosol map
  3. FOS|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. AP1*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. HMGB1@default map


References
PMID:16327802
IL13 and TNF together (but neither IL-13 nor TNF alone) upregulates TGFB1 expression downstream of IL13RA2.
IL13 and TNF inducese TGFB1 expression via AP-1 transcription factors.IL13 induces binding of c-jun and fra2 ti TGFB1 promotor, and TNF binding of c-jun, JunD and c-fos.
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages via TLR4-dependent mechanisms.