Identifiers
HUGO:CXCR4
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / INFLAMMATORY_SIGNALING_PATHWAYS
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / RECRUITMENT_OF_IMMUNE_CELLS
References
CASCADE:CXCL12
PMID:20535745
CXCR4 receptor and CXCL12 both are expressed in fibroblasts and probably provides positive loop in fibroblast activation
and promotes RhoA-activation aand actin polymerisation.
PMID:20644254
HIF2a induces macrophage migration via upregulation of CXCR4, FN1 expression and upregulation of M-CSFR protein level.
PMID:22025564
PGE(2) was essential both for expression of functional CXCR4 in cancer-associated MDSCs and for production of its ligand CXCL12. Frequencies of CD11b(+)CD14(+)CD33(+)CXCR4(+) MDSCs closely correlated with CXCL12 and PGE(2) levels in patient ascites. MDSCs migrated toward ovarian cancer ascites in a CXCR4-dependent manner that required COX2 activity and autocrine PGE(2) production.
PMID:17035340
The secretion of HMGB1 is required for the migration of maturing dendritic cells.
myeloid DC, which rapidly secrete upon maturation induction their own HMGB1, remodel their actin-based cytoskeleton, up-regulate the CCR7 and the CXCR4 chemokine receptors, and acquire the ability to migrate in response to chemokine receptor ligands. The events are apparently causally related: DC challenged with LPS in the presence of HMGB1-specific antibodies fail to up-regulate the expression of the CCR7 and CXCR4 receptors and to rearrange actin-rich structures. Moreover, DC matured in the presence of anti-HMGB1 antibodies fail to migrate in response to the CCR7 ligand CCL19 and to the CXCR4 ligand CXCL12
→ CXCR4@INNATE_IMMUNE_CELL_Membrane
→ CXCR4@INNATE_IMMUNE_CELL_Cytosol
→ RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol
+ CXCR4@INNATE_IMMUNE_CELL_Membrane → CXCL12:CXCR4@INNATE_IMMUNE_CELL_Membrane