KIR2DL1

Protein KIR2DL1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / MARKERS_NK

References
CASCADE:KIR2DL1
NATURAL_KILLER
PMID:11513144
KIRs constitute a family of slightly polymorphic receptors with distinct MHC-I-binding profiles for classical HLA-A, HLA-B, and HLA-C molecules. Most KIRs with two Ig domains (KIR2DL) recognize subsets of the HLA-C allotypes.
PMID:16606694
WIPF1 forms complex with WASP. Protein kinase C-theta mediates phosphorylation of WIPF1 downstream of NK activation. Inhibitory signaling from KIR2DL1 receptor
PMID:12917349, PMID:18835194
Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition
of cellular cytotoxicity downstream of KIR-receptor (KIR2DL1).
PMID:12515815
Coengagement of inhibitory receptor KIR2DL1 blocked 2B4 phosphorylation and downstream signaling.
PMID:9751747
KIR2DL3, KIR2DL1, KIR2DS4, KIR3DL1, KIR3DL2, KIR2DL4 interact with SHP-2 in NK cells
and probably are phosphorylated by LCK 5directly demonstrated for KIR2DL3 only.
(CL6 = KIR2DL3,CL42 =KIR2DL1, CL39 = KIR2DS4, NKAT3= KIR3DL1, NKAT4 = KIR3DL2,KIR103AS=KIR2DL4)

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane

KIR2DL1@INNATE_IMMUNE_CELL_Membrane

In compartment: MARKERS_NK

KIR2DL1@MARKERS_NK

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane

HLA-C:KIR2DL1|pho@INNATE_IMMUNE_CELL_Membrane

Participates in reactions:
As Reactant or Product:

HLA-C@TUMOR_CELL_AS_INDUCTOR_Membrane + KIR2DL1@INNATE_IMMUNE_CELL_Membrane → HLA-C:KIR2DL1|pho@INNATE_IMMUNE_CELL_Membrane

As Catalyser: