Complex HLA-C:KIR2DL1 map
Complex composition:

  1. KIR2DL1 map
  2. HLA-C map

HLA-C:​KIR2DL1|​pho@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:HLA-C:KIR2DL1

References
CASCADE:KIR2DL1
 NATURAL_KILLER  map
PMID:12917349, PMID:18835194
KIR2DL1 signaling provides Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 and inhibits NK cytotoxicity.
PMID:9751747
Potentially KIR2DL1 can acts also via SHP-2
PMID:12515815
Coengagement of inhibitory receptor KIR2DL1 blocked 2B4 phosphorylation and downstream activating signaling .

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. HLA-C:​KIR2DL1|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. HLA-C@TUMOR_CELL_AS_INDUCTOR_Membrane map + KIR2DL1@INNATE_IMMUNE_CELL_Membrane map → map HLA-C:​KIR2DL1|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map + 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
  2. PTPN6@INNATE_IMMUNE_CELL_Cytosol map → map PTPN6@INNATE_IMMUNE_CELL_Cytosol map
  3. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map
  4. ABL1@INNATE_IMMUNE_CELL_Cytosol map → map ABL1@INNATE_IMMUNE_CELL_Cytosol map
  5. WASP*|​pho:​WIPF1@INNATE_IMMUNE_CELL_Cytosol map → map WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map