Identifiers
HUGO:PRKCQ
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / SMAC
Adaptive Immune Response / TCR_SIGNALING
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:23433459 PMID:23886063 9738502?? PMID:17544292 PMID:23474202 PMID:15536066 PMID:10652356 PMID:15214048
NATURAL_KILLER
CASCADE:IFNAB
PMID:25960930
IFN?? induces PKC-?? auto-phosphorylation in NK cells via P3K and PLC pathways and improves the degranulation via PKC-?? signaling
Reduced IFN??-induced STAT-1 phosphorylation in Ser727 and CXCL10 secretion in NK cells derived from PKC-?????/??? mice
PMID:19201850
Protein kinase C-theta is required for NK cell activation and in vivo control of tumor progression.
PRKCQ upregulates granzyme A and B expression in NK cells recruited to the tumor environment.
PRKCQ could be activated downstream of IL15 and TLR3 signaling.
PMID:16606694
WIPF1 forms complex with WASP. Protein kinase C-theta mediates phosphorylation of WIPF1 downstream of NK activation. Inhibitory signaling from KIR2DL1 receptor.
PMID:18784374; PMID:23077238, PMID:17548359
PKC-theta requires DAG for activation. DAG is generated by PLCG through enzymatic cleavage of PIP2.
PMID:18784374
PKC-theta???mediated signals activate AP-1 and NFAT1.
The capacity of NFAT to bind DNA was reduced in PKC-theta???de???cient NK cells.
There is a signi???cant decrease in AP-1 activation in PKC-theta???de???cient NK cells.
+ PRKCQ@INNATE_IMMUNE_CELL_Cytosol → DAG:PRKCQ@INNATE_IMMUNE_CELL_Cytosol
→ DAG:PRKCQ|pho@INNATE_IMMUNE_CELL_Cytosol
→ rIRF9@INNATE_IMMUNE_CELL_Cytosol
→ NFAT*@INNATE_IMMUNE_CELL_Cytosol
→ STAT1|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ WASP*|pho:WIPF1|pho@INNATE_IMMUNE_CELL_Cytosol
→ GZMB@SECRETORY_GRANULE
→ GZMA@SECRETORY_GRANULE