Protein KLRB1 map

Identifiers
HUGO:KLRB1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / MARKERS_NK  map

References
 NATURAL_KILLER  map
CASCADE:KLRB1
CASCADE:IL12
PMID:18159636
Transcription of the KLRB1 gene is suppressed in human cancer tissues
PMID:16339513
CLEC2D (LLT1) is a ligand for the inhibitory human KLRB1 (NKR-P1A) receptor.
LLT1 inhibits NK cytotoxicity induced by either the 2B4(CD48/CD244) pathway or the MICA/NKG2D pathway.
PMID:9603467
IL-12-induced up-regulation of NKRP1A expression
in human NK cells and consequent NKRP1Amediated down-regulation of NK cell activation.
NKRP1A-induced inhibition of CD16 or p46 mediated cytolytic activity.
PMID:22378844, PMID:24227772
miR-155 is synergistically induced in primary human NK cells after costimulation with IL-12 and IL-18, or with IL-12 and CD16 clustering.
IL15 and KLRB1 (NK1.1) ligation also induce MIR155 expression.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KLRB1@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_NK
  1. KLRB1@MARKERS_NK map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CLEC2D:​KLRB1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. KLRB1@INNATE_IMMUNE_CELL_Membrane map + CLEC2D@TUMOR_CELL_AS_INDUCTOR_Membrane map → map CLEC2D:​KLRB1@INNATE_IMMUNE_CELL_Membrane map
  2. rKLRB1@INNATE_IMMUNE_CELL_Cytosol map → map KLRB1@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gMIR15/16*@INNATE_IMMUNE_CELL_Cytosol map → map arMIR15/16*@INNATE_IMMUNE_CELL_Cytosol map
  2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  3. GRB2@INNATE_IMMUNE_CELL_Cytosol map + DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map → map DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  4. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  5. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map + 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
  6. gMIR155@INNATE_IMMUNE_CELL_Cytosol map → map arMIR155@INNATE_IMMUNE_CELL_Cytosol map