Antisense RNA MIR155 map

Identifiers
HUGO:MIR155
microRNA 155
HUGO:MIR155 HGNC:31542 ENTREZ:406947

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / MIRNA_TF_IMMUNOSTIMULATORY  map

References
PMID:23171795
Downregulation of miR-31 and miR-214 and upregulation of miR-155 was confirmed in all CAF and induced CAF samples;
CCL5 is a Target of miR-214 . The CCL5 secreted by CAFs is a key tumor-promoting factor.
PMID:26589288
MiR-155 knockout also inhibits cardiac fibroblast proliferation and differentiation into myofibroblasts.
PMID:26195069
Pancreatic cancer-secreted miR-155 implicates in the conversion from normal fibroblasts to cancer-associated fibroblasts.
PMID:24272429
PMID:23665507
PMID:23377965
PMID:24206455
PMID:23453900
PMID:21145728
PMID:22902544
PMID:23550650
 NATURAL_KILLER  map
 MACROPHAGE  map
CASCADE:IL10
CASCADE:IL4
CASCADE:IL13
CASCADE:KLRB1
PMID:24227772
KLRB1 (NK1.1) ligation also induce MIR155 expression
PMID:23422749
The enhanced NK-cell survival, expansion, activation, and tumor control result from overexpression of miR-155 in NK cells.
PMID:19359473, PMID:22378844, PMID:24227772
Inositol phosphatase SHIP1 is a primary and direct target of miR-155.
miR-155 upregulates IFNG production in natural killer cells via SHIP1 downregulation.
Inhibition of either calcineurin or PI3Kled to a dose-responsive decrease in the differential between 155???/??? and WT NK cell
But an the same time mRNAs targeted by miR-155 were enriched in NK cell activation signaling pathways.
SLP76, IKBKE mRNA are MIR55 targets.
PMID:23572582
NOXA , a proapoptotic Bcl-2 homology domain (BH3)-only protein, is an important regulator of survival in NK cells
ans SOCS1 are mir155 targets in NK cells
PMID:21097505
miR-155 Directly Targets IL13RA1, reduces the IL-13- and IL-4-dependent Phosphorylation of STAT6 in Human Macrophages and downregulates IL-13 dependent GENES
PMID:21385848
miR155 induction is required for efficient DC maturation and is critical for the ability of DCs to promote antigen-specific T-cell activation.
miR155 expression was increased strongly in mature Mo-DCs relative to monocytes and immature Mo-DCs.

arMIR155@INNATE_IMMUNE_CELL_Cytosol

References
in_re431( Innate Immunity  map ):
PMID:20435894
IL10 inhibits miR155 expression via STAT3.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. arMIR155@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. LCP2:​MIR155@INNATE_IMMUNE_CELL_Cytosol map
  2. MIR155:​SHIP1*@INNATE_IMMUNE_CELL_Cytosol map
  3. IL13RA1:​MIR155@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. LCP2:​MIR155@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  2. arMIR155@INNATE_IMMUNE_CELL_Cytosol map + rLCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2:​MIR155@INNATE_IMMUNE_CELL_Cytosol map
  3. MIR155:​SHIP1*@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  4. arMIR155@INNATE_IMMUNE_CELL_Cytosol map + rSHIP1*@INNATE_IMMUNE_CELL_Cytosol map → map MIR155:​SHIP1*@INNATE_IMMUNE_CELL_Cytosol map
  5. gMIR155@INNATE_IMMUNE_CELL_Cytosol map → map arMIR155@INNATE_IMMUNE_CELL_Cytosol map
  6. rIL13RA1@INNATE_IMMUNE_CELL_Cytosol map + arMIR155@INNATE_IMMUNE_CELL_Cytosol map → map IL13RA1:​MIR155@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: