WASP*

Protein WASP*

Identifiers
HUGO:WAS
Wiskott-Aldrich syndrome
HUGO:WAS hgnc_id:HGNC:12731 HGNC:12731 ENTREZ:7454 UNIPROT:P42768
IMD2, THC, "thrombocytopenia 1 (X-linked)", "Wiskott-Aldrich syndrome (eczema-thrombocytopenia)"
HUGO:WAS HGNC:12731 ENTREZ:7454 UNIPROT:P42768

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MOTILITY
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY

References
PMID:11520460 PMID:14707117
PMID:21178402
Rac1 and Cdc42 activate ARP2/3 complex;
Rac1 and Cdc42 activate Wiskott-Aldrich Syndrome family of proteins including WASP, N-WASP and WAVE1/2.
PMID:11395419
Arp2/3 complex is intrinsically inactive, relying on nucleation promoting factors for activation. WASp/Scar family proteins are prominent cellular nucleation promoting factors. They bring together an actin monomer and Arp2/3 complex in solution or on the side of an existing actin filament to initiate a new filament that grows in the barbed end direction.
PMID:23212475
WAve and WASP proteins activate Arp2/3 complex
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
NATURAL_KILLER
MACROPHAGE
CASCADE:CR3
CASCADE:Fc_gamma_RII
CASCADE:KIR2DL1
PMID:15001467, PMID:14707117
CD16 or ITGB2 (CD18) stimulation resulted in the induction of WASp tyrosine phosphorylation in NK cells,
probubly by Fyn. Fyn enhanced WASp-mediated Arp2/3 activation and was required for synapse formation in T cells.
PMID:12177428
NK cell cytotoxicity was deficient in WAS patients and WASp catalyzes actin polymerization.
It binds actin monomers as well as the actin-related protein (ARP) 2/3 complex to catalyze branching of filamentous actin (F-actin)
PMID:16606694
WIPF1 forms complex with WASP.
PMID:19741094
t Cdc42 is essential for the activation of WASP and N-WASP, leading to actin assembly and phagocytic cup formation by macrophages during Fc(gamma)R-mediated phagocytosis.
Cdc42 Is Required for Activation and Tyrosine Phosphorylation of WASP/N-WASP

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

WASP*@INNATE_IMMUNE_CELL_Cytosol
WASP*|pho|active@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: