Protein TRIP10 map

Identifiers
HUGO:TRIP10

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map

References
PMID:17785506 PMID:10713100 PMID:15541654
 NATURAL_KILLER  map
PMID:17785506
Cdc42-interacting protein-4 (CIP4) - TRIP10 is able to associate with Wiskott-Aldrich syndrome protein (WASp) and the actin filament-rich IS.
WASP is needful for TRIP10 activation. CIP4 in NK provides cell cytotoxicity and MTOC polarization but not F-actin accumulation.
TRIP10 (CIP4) functions downstream of Cdc42 to induce MTOC polarization to the IS and cytotoxicity.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TRIP10@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TRIP10:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + TRIP10@INNATE_IMMUNE_CELL_Cytosol map → map TRIP10:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol map → map MTOC_polarization@INNATE_IMMUNE_CELL_Cytosol map