Complex ITGAV:ITGB5:MFGE8 map
Complex composition:

  1. MFGE8 map
  2. ITGAV map
  3. ITGB5 map

ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:ITGAV:ITGB5:MFGE8

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / INTEGRINS  map
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
 DENDRITIC_CELL  map
CASCADE:INTEGRIN_AVB5
PMID:14697347, PMID:11146654
Integrin ??v??5 regulates phagocytosis via CRK /DOCK1 (DOCK180) /RAC1 pathway downstream of.
Integrin ??v??5 activation results in recruitment of the p130cas???CrkII???Dock180 complex and RAC1 activation.
in_re1( Innate Immunity  map ):
PMID:10837075
Immature DCs are very efficient in Ag capture and can use several pathways, such as (a) macropinocytosis; (b) receptor-mediated endocytosis via C-type lectin receptors (mannose receptor, DEC-205)
or Fc?? receptor types I (CD64) and II (CD32) [uptake of immune complexes or opsonized particles ]; and (c) phagocytosis of particles such as latex beads , apoptotic and necrotic cell fragments (involving CD36 and ??v??3 or ??v??5 integrins), viruses, and bacteria including mycobacteria, as well as intracellular parasites such as Leishmania major. DCs can also internalize the peptide loaded heat shock proteins gp96 and Hsp70 through presently unknown mechanisms

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. ITGAV:​ITGB5@INNATE_IMMUNE_CELL_Membrane map + MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane map → map ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → map Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. CRK@INNATE_IMMUNE_CELL_Cytosol map + DOCK1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map