Identifiers
integrin subunit alpha V
HUGO:ITGAV hgnc_id:HGNC:6150 HGNC:6150 ENTREZ:3685 UNIPROT:P06756
integrin, alpha V
"antigen identified by monoclonal antibody L230", "integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)", MSK8, "vitronectin receptor", VNRA, VTNR
HUGO:ITGAV HGNC:6150 ENTREZ:3685 UNIPROT:P06756 GENECARDS:GC02P187418
HUGO:ITGAV
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_MATRIX_ADHESIONS
EMT Senescence / ECM
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / INTEGRINS
Innate Immunity / DANGER_SIGNAL_PATHWAYS
References
CASCADE:INTEGRIN
PMID:18353785
Transforming Growth Factor ??1 Induces ??v??3 Integrin Expression in Human Lung Fibroblasts via a ??3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway*
DENDRITIC_CELL
CASCADE:INTEGRIN_AVB5
CASCADE:INTEGRIN_AVB3
PMID:9295024, PMID:9763615
Dendritic cells phagocytose apoptotic cells via alphavbeta5, alphavbeta3, and CD36.
The interaction between apoptotic bodies and dendritic cells elicits a rise in intracellular free calcium concentration ([Ca2+]i) which is essential for the process of engulfment.
+ MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane + ITGAV:ITGB3@INNATE_IMMUNE_CELL_Membrane → ITGAV:ITGB3:MFGE8:PtdSer@INNATE_IMMUNE_CELL_Membrane
→ EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane
+ MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane → ITGAV:ITGB5:MFGE8@INNATE_IMMUNE_CELL_Membrane