Protein ITGB5 map

Identifiers
integrin subunit beta 5
HUGO:ITGB5 hgnc_id:HGNC:6160 HGNC:6160 ENTREZ:3693 UNIPROT:P18084
integrin, beta 5
HUGO:ITGB5 HGNC:6160 ENTREZ:3693 UNIPROT:P18084
HUGO:ITGB5

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / INTEGRINS  map
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
CASCADE:INTEGRIN
CASCADE:PLAU
PMID:22470492
Degradation of internalized ??v??5 integrin is controlled by uPAR bound uPA: effect on ??1 integrin activity and ??-SMA stress fiber assembly.
uPA (PLAU) signaling has a negative influence on myofibroblast differentiation;
 DENDRITIC_CELL  map
PMID:9295024, PMID:9763615
Dendritic cells phagocytose apoptotic cells via alphavbeta5, alphavbeta3, and CD36.
The interaction between apoptotic bodies and dendritic cells elicits a rise in intracellular free calcium concentration ([Ca2+]i) which is essential for the process of engulfment.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGAV:​ITGB5@INNATE_IMMUNE_CELL_Membrane map
  2. ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. ITGAV:​ITGB5@INNATE_IMMUNE_CELL_Membrane map + MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane map → map ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → map Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. CRK@INNATE_IMMUNE_CELL_Cytosol map + DOCK1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map