Identifiers
NAME:CYBA:CYBB:FAD:GTP:NCF1:NCF2:NCF4:RAC1_2*:heme
References
DENDRITIC_CELL
PMID:19372727
The enzyme responsible for O2???- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.
The regulation of phagosomal pH exerted by NOX2, and thereby of the efficacy of antigen cross-presentation in DCs, represents a clear illustration of how NOX2 can influence CD8(+) T lymphocyte responses.
PMID:22157818
Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner.
PMID:22157818, PMID:22827577
CTSS (cathepsin S), CTSB (cathepsin B) and CTSL (cathepsin L) are active in DC phagosomes.
Phagosomal NOX2 activity via ROS inhibits the activities of local cysteine (B/S/L ), but not aspartic (D/E), cathepsins.
Identifiers
NAME:CYBA:CYBB:FAD:GTP:NCF1:NCF2:NCF4:RAC1_2*:heme
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / NO_ROS_PRODUCTION
References
MACROPHAGE
MDSC
CASCADE:S100A
PMID:19372727
The enzyme responsible for O2???- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.
PMID:19380816, PMID:21383238
The increased ROS production by MDSC is mediated by up-regulated activity of NADPH oxidase (NOX2).
STAT3 upregulates expression of NOX2 subunits, primarily p47(NCF1) and gp91(CYBB) in MDSC,
In the absence of NOX2 activity, MDSC lost the ability to suppress T cell responses and quickly differentiated into mature macrophages and dendritic cells.
PMID:18809714
S100A9 regulates myeloid cell differentiation via reactive oxygen species (ROS), probabli via NAPDH oxidase.
in_re477( Innate Immunity ):
PMID:19732719
Inhibition of TGF-?? signaling??in vivo??increases CD11b+??cell cytotoxicity via an oxygen radical-dependent mechanism (superoxide?? and H2O2 production) in neutrophils
+ NCF2@INNATE_IMMUNE_CELL_Cytosol + NCF4@INNATE_IMMUNE_CELL_Cytosol + CYBA@INNATE_IMMUNE_CELL_Cytosol + NCF1@INNATE_IMMUNE_CELL_Cytosol + CYBB@INNATE_IMMUNE_CELL_Cytosol + FAD@INNATE_IMMUNE_CELL_Cytosol + heme@INNATE_IMMUNE_CELL_Cytosol → CYBA:CYBB:FAD:GTP:NCF1:NCF2:NCF4:RAC1_2*:heme@INNATE_IMMUNE_CELL_Cytosol