Protein NCF2 map

Identifiers
neutrophil cytosolic factor 2
HUGO:NCF2 HGNC:7661 ENTREZ:4688 UNIPROT:P19878
HUGO:NCF2

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / NECROPTOSIS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / NO_ROS_PRODUCTION  map

References
synonym:p67phox synonym:NOXA2
 DENDRITIC_CELL  map
PMID:19372727
The enzyme responsible for O2???- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NCF2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CYBA:​CYBB:​FAD:​GTP:​NCF1:​NCF2:​NCF4:​RAC1_2*:​heme@INNATE_IMMUNE_CELL_Cytosol map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. CYBA:​CYBB:​FAD:​GTP:​NCF1:​NCF2:​NCF4:​RAC1_2*:​heme@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in reactions:
As Reactant or Product:
  1. GTP:​RAC1_2*@INNATE_IMMUNE_CELL_Cytosol map + NCF2@INNATE_IMMUNE_CELL_Cytosol map + NCF4@INNATE_IMMUNE_CELL_Cytosol map + CYBA@INNATE_IMMUNE_CELL_Cytosol map + NCF1@INNATE_IMMUNE_CELL_Cytosol map + CYBB@INNATE_IMMUNE_CELL_Cytosol map + FAD@INNATE_IMMUNE_CELL_Cytosol map + heme@INNATE_IMMUNE_CELL_Cytosol map → map CYBA:​CYBB:​FAD:​GTP:​NCF1:​NCF2:​NCF4:​RAC1_2*:​heme@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map