Identifiers
HUGO:CYBA
cytochrome b-245, alpha polypeptide
HUGO:CYBA HGNC:2577 ENTREZ:1535 UNIPROT:P13498
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / METABOLIC
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / NECROPTOSIS
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / NO_ROS_PRODUCTION
References
PMID:15927447
Nox4, in contrast to other Nox proteins, produces large amounts of hydrogen peroxide constitutively. Known cytosolic oxidase proteins or the GTPase Rac are not required for this activity. Nox4 associates with the protein p22phox on internal membranes, where ROS generation occurs. Knockdown and gene transfection studies confirmed that Nox4 requires p22phox for ROS generation.
synonym:p22phox
DENDRITIC_CELL
PMID:19372727
The enzyme responsible for O2???- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.
+ NCF2@INNATE_IMMUNE_CELL_Cytosol + NCF4@INNATE_IMMUNE_CELL_Cytosol + CYBA@INNATE_IMMUNE_CELL_Cytosol + NCF1@INNATE_IMMUNE_CELL_Cytosol + CYBB@INNATE_IMMUNE_CELL_Cytosol + FAD@INNATE_IMMUNE_CELL_Cytosol + heme@INNATE_IMMUNE_CELL_Cytosol → CYBA:CYBB:FAD:GTP:NCF1:NCF2:NCF4:RAC1_2*:heme@INNATE_IMMUNE_CELL_Cytosol