Protein PPARG map

Identifiers
HUGO:PPARG

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map

References
PMID:17681149
PPARG upregulates expression of M2 markers CD163 and MRC1 downstream of IL4.
PPARG participates in inhibition of secretion of proinflammatory molecules, such as CCL3, TNF, and CCL2(MCP1)

PPARG@INNATE_IMMUNE_CELL_Cytosol

References
in_re1105( Innate Immunity  map ):
PMID:10432118
Linoleic acid is oxygenated by ALOX15 to 13-HODE which activates PPARG.
in_re1039( Innate Immunity  map ):
PMID:23390297
MIF induces expression of M2 markers ARG1, IL10, stabilin-1, MRC-1, CD23.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PPARG@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PPARG:​SUMO*@INNATE_IMMUNE_CELL_Cytosol map
  2. PPARG:​STAT6|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. HDAC3:​NCOR1:​PPARG:​SUMO*:​TBL1X:​TBL1XR1@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PPARG@INNATE_IMMUNE_CELL_Cytosol map → map PPARG@INNATE_IMMUNE_CELL_Cytosol map
  2. rPPARG@INNATE_IMMUNE_CELL_Cytosol map → map PPARG@INNATE_IMMUNE_CELL_Cytosol map
  3. STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + PPARG@INNATE_IMMUNE_CELL_Cytosol map → map PPARG:​STAT6|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. PPARG:​SUMO*@INNATE_IMMUNE_CELL_Cytosol map + HDAC3:​NCOR1:​TBL1X:​TBL1XR1@INNATE_IMMUNE_CELL_Cytosol map → map HDAC3:​NCOR1:​PPARG:​SUMO*:​TBL1X:​TBL1XR1@INNATE_IMMUNE_CELL_Cytosol map
  5. PPARG@INNATE_IMMUNE_CELL_Cytosol map + SUMO*@INNATE_IMMUNE_CELL_Cytosol map → map PPARG:​SUMO*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  2. gCD163@MARKERS_MACROPHAGE map → map rCD163@MARKERS_MACROPHAGE map
  3. gMRC1@MARKERS_MACROPHAGE map → map rMRC1@MARKERS_MACROPHAGE map
  4. CCL3@INNATE_IMMUNE_CELL_Cytosol map → map CCL3@default map
  5. gCD36@INNATE_IMMUNE_CELL_Cytosol map → map rCD36@INNATE_IMMUNE_CELL_Cytosol map
  6. CCL2@INNATE_IMMUNE_CELL_Cytosol map → map CCL2@default map
  7. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
  8. gCCL3@INNATE_IMMUNE_CELL_Cytosol map → map rCCL3@INNATE_IMMUNE_CELL_Cytosol map
  9. gCCL7@INNATE_IMMUNE_CELL_Cytosol map → map rCCL7@INNATE_IMMUNE_CELL_Cytosol map
  10. gCXCL10@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL10@INNATE_IMMUNE_CELL_Cytosol map