Protein RLC_MYOSIN_II* map

Identifiers
HUGO:MYL9 HUGO:MYL12A HUGO:MYL12B
myosin light chain 9
HUGO:MYL9 hgnc_id:HGNC:15754 HGNC:15754 ENTREZ:10398 UNIPROT:P24844
myosin light chain 12A
HUGO:MYL12A hgnc_id:HGNC:16701 HGNC:16701 ENTREZ:10627 UNIPROT:P19105
myosin light chain 12B
HUGO:MYL12B hgnc_id:HGNC:29827 HGNC:29827 ENTREZ:103910 UNIPROT:O14950

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MOTILITY  map

References
PMID:25712372 PMID:19349987
PMID:25712372
In mammals,
three genes (MYH9, MYH10, MYH14) encode for three
non-muscle myosin-2 isoforms referred to as -2A, -2B, and -
2C, respectively. Most cells simultaneously express two or
three non-muscle myosin-2 paralogs and their splice variants
in a strictly regulated manner. Each mammalian non-muscle
myosin-2 heavy chain associates with one ELC encoded by
one of two genes (MYL6, MYL6B) and with one RLC
encoded by either MYL9, MYL12A, or MYL12B.
MLCK and ROCK phosphorylares RLC
PMID:21840487
JAK1 expression with four different siRNAs reduced MLC2 phosphorylation
PMID:24857661
Long-term stimulation of both TGF-?? and LIF cytokines also upregulated RhoA small GTPase and myosin light chain 2 (MLC2) proteins, leading to an increase in MLC2 phosphorylation at ser19, which attests for an increased activity (Figure S2D). Finally, forced expression of an active form of ROCK (ROCK-ER) (Croft and Olson, 2006) following 4-hydroxytamoxifen (4OHT) treatment was sufficient to induce hDF contractility (Figure S2E), proinvasive capacity (Figures S2Fa and b), and MLC2 phosphorylation (Figure S2G) and also rescued the inhibitory effect of P6 or anti-LIF antibody treatments under TGF-??1 stimulation
 MACROPHAGE  map
CASCADE:CR3

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map
  2. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map + WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. ELC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map + RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map + MYH9|​hm2@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map
  3. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@INNATE_IMMUNE_CELL_Cytosol map + WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map