Protein IRF8 map

Identifiers
HUGO:IRF8

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSTIMULATORY  map

References
 MACROPHAGE  map
 MDSC  map
CASCADE:GSF3
CASCADE:GSF2
CASCADE:IFNG
CASCADE:TLR2_4
PMID:24091328
(a) Irf8-deficient mice generated myeloid populations highly homologous to tumor-induced MDSCs with respect to phenotype, function, and gene expression profiles; (b) IRF-8 overexpression in mice attenuated MDSC accumulation and enhanced immunotherapeutic efficacy; (c) the MDSC-inducing factors G-CSF and GM-CSF facilitated IRF-8 downregulation via STAT3- and STAT5-dependent pathways; and (d) IRF-8 levels in MDSCs of breast cancer patients declined with increasing MDSC frequency, implicating IRF-8 as a negative regulator in human MDSC biology.
IRF-8 levels are depressed in MDSCs of breast cancer patients.
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
PMID:16597464
IRF-8 and IRF-1 are the target genes in activated macrophages.
The expression levels of CXCL16, H28, IL-17R, LIF, MAP4K4, MMP9, MYC, PCDH7, PML, and SOCS7 were signi???cantly increased in macrophages
extracted form WT mice (black columns) following activation
for 4 h with IFNG and LPS. However, no changes in the expression of these genes were observed in cells extracted from IRF-8,
as well as from IRF-1 null mice.
PMID:10734131
PU.1 (SPI1) together with IRF8 relulates TLR4 expression in myeloid cells

IRF8@INNATE_IMMUNE_CELL_Cytosol

References
in_re558( Innate Immunity  map ):
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:16413922
NFKBID (IkBNS) inhibit late phase (after 3h) of expression of proinflanotory cytokines
Il-12p40 (IL-12p40), Il-18 (IL-18) and Csf3 (G_CSF).
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:23390297
MIF inhitits expression of M1 markers such as IL12p40
in_re629( Innate Immunity  map ):
PMID:11875494
HMOX1 (HO1) mediates IL-10-induced suppression
of MMP9 expression.
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.
in_re703( Innate Immunity  map ):
PMID:11964313, PMID:11672593, PMID:12032143, PMID:12811837.
INFG upregulates mRNA level and surface expression of TLR4 and TLR2.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IRF8@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIRF8@INNATE_IMMUNE_CELL_Cytosol map → map IRF8@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gCXCL16@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL16@INNATE_IMMUNE_CELL_Cytosol map
    2. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
    3. gMMP9@INNATE_IMMUNE_CELL_Cytosol map → map rMMP9@INNATE_IMMUNE_CELL_Cytosol map
    4. gTLR4@INNATE_IMMUNE_CELL_Cytosol map → map rTLR4@INNATE_IMMUNE_CELL_Cytosol map
    5. gMYC@INNATE_IMMUNE_CELL_Cytosol map → map rMYC@INNATE_IMMUNE_CELL_Cytosol map